Can one keyboard shortcut open PIP windows for several virtual screens?

Yes. Use a separate CLI command for each screen, with its name in the command. Run the commands together from a macOS shortcut. You can then open both windows without moving the pointer between desktops.

Start BetterDisplay, connect both virtual screens and enable Pro. Grant Screen Recording permission if needed. These commands open each screen’s default PIP window:

betterdisplaycli set -name="Virtual Left" -pip=on
betterdisplaycli set -name="Virtual Right" -pip=on

Replace the example names with distinct names from your setup. Use -pip=off to close the windows. If you want a different saved PIP configuration for a display, add its identifier, such as -specifier=2. Create that configuration in BetterDisplay first. If you omit the identifier, the command selects configuration 1.

In macOS Shortcuts, add a Run Shell Script action containing both commands and assign the shortcut a keyboard shortcut. Use the actual absolute path to your installed betterdisplaycli executable in that action, since Shortcuts may not use your Terminal shell’s search path. Check each command’s result and confirm that both windows appear.

If you want PIPs to reopen when an associated display reconnects, use Start Automatically and follow automatic PIP startup troubleshooting. See CLI PIP examples and Shortcuts with the CLI for setup and more window options.